- Illustration of the damage to the biliary tract
- Bile duct damage Open popup dialog
- Primary sclerosing cholangitis (skluh-ROHS-ing) (koh-lan-JIE-tis) is a disease of the biliary tract. The biliary tract carries liquid digestive bile from your liver to your small intestine. In primary sclerosing cholangitis, inflammation causes scars in the bile ducts. These scars make the canals hard and narrow and gradually lead to severe liver damage. The majority of people with primary sclerosing cholangitis also have inflammatory bowel diseases such as ulcerative colitis or Crohn’s disease. Sclerosing cholangitis treatment in hyderabad
Primary sclerosing cholangitis is often diagnosed before symptoms appear when a routine blood test or x-ray done for an unrelated condition reveals liver abnormalities.
- The first signs and symptoms are often:
Yellow eyes and skin (jaundice)
It is not known what causes primary sclerosing cholangitis. An immune system response to an infection or a toxin can cause disease in people who are genetically predisposed to it.
A large proportion of people with primary sclerosing cholangitis also have inflammatory bowel disease, an umbrella term that includes ulcerative colitis and Crohn’s disease.
However, primary sclerosing cholangitis and inflammatory bowel disease do not always occur at the same time. In some cases, primary sclerosing cholangitis has existed for years before inflammatory bowel disease occurs. If primary sclerosing cholangitis is diagnosed, it is important to check for inflammatory bowel disease as the risk of colon cancer is higher. Sclerosing cholangitis treatment in hyderabad
Factors that can increase your risk of developing primary sclerosing cholangitis include:
Age. Primary sclerosing cholangitis can occur at any age, but is most commonly diagnosed between the ages of 30 and 40.
Sex. Primary sclerosing cholangitis is more common in men.
Inflammatory bowel disease. A large proportion of people with primary sclerosing cholangitis also suffer from inflammatory bowel disease.
Geographical position. People of northern European descent are at greater risk for primary sclerosing cholangitis.
Complications of primary sclerosing cholangitis can include:
Liver disease and failure. Chronic inflammation of the biliary tract in your liver can lead to tissue scarring (cirrhosis), death of liver cells, and possibly loss of liver function.
Repeated infections. When the scarring of the biliary tract slows or stops the flow of bile from the liver, common biliary tract infections can occur. The risk of infection is particularly high after surgery to widen a severely scarred bile duct or to remove a stone that is blocking a bile duct. Sclerosing cholangitis treatment in hyderabad